Costa Adeje is the nicest area for most visitors. It is warmer than the north, more settled than the party strips, and easier to use as a base.
You can have beach days, meals out, and simple transport without much stress. Some people will prefer Puerto de la Cruz for a more local feel, but it is cooler and less beach focused.
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If you want the smoothest all round stay, Costa Adeje is the one I would point to first.