Costa Adeje is the nicest area to stay for a lot of people. It is warm, practical, and less messy than the livelier parts of the south.
You can still reach the party areas if you want them, but you do not have to sleep right in the middle of them. If you prefer more local character, Puerto de la Cruz or La Laguna are good alternatives.
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For one answer that suits the widest range of travellers, Costa Adeje is the one I would pick.