Costa Adeje is the easiest answer again. It has the best mix of weather, beaches, restaurants, and straightforward holiday convenience.
If you want somewhere that feels comfortable without needing to think too much, this is the place most people mean. Puerto de la Cruz is a good second choice if you want something more local and a bit less touristy.
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The nicest part depends on your style, but Costa Adeje is the safest all round bet.