Costa Adeje is better if you want a cleaner, calmer, more polished stay. Los Cristianos is better if you want a more lived in feel, a busier promenade, and usually a bit less spent on food and drinks.
Honestly, Costa Adeje feels like the safer pick for couples or anyone who wants a nicer hotel and easier evenings. Los Cristianos is the one I’d choose if I wanted a more casual base with plenty going on and a bit more character. If you want beaches, bars, and convenience, both work.
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If you want the nicer overall vibe, Costa Adeje wins.